2,4-Dinitrophenol (DNP) is a yellow crystalline powder that has a sweet, musty odour and is soluble in water. The dose of DNP per capsule is 100 or 200 mg. DNP is a weight loss agent with significant acute toxicity. A typical regimen would include starting with one capsule of DNP for the first few days followed by increasing doses to a recommended maximum of 400 mg/day, which is then used for up to 2 weeks in duration.
Data of DNP Powder:
CAS ID: 51-28-5
Melting point: 108-112 °C
Purity: Pure crystalline (100% dry) DNP;
Powdered DNP (usually 5-10% moisture).
Appearance: Yellow or pale yellow monoclinic crystal or powder.
Usage of DNP Powder:
2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects.
DNP is sold mostly over the internet under a number of different names as a weight loss/slimming aid. It causes uncoupling of oxidative phosphorylation; the classic symptom complex associated with toxicity of phenol-based products such as DNP is a combination of hyperthermia, tachycardia, diaphoresis and tachypnoea, eventually leading to death.
Fatalities related to exposure to DNP have been reported since the turn of the twentieth century. To date, there have been 62 published deaths in the medical literature attributed to DNP. In this review, we will describe the pattern and pathophysiology of DNP toxicity and summarise the previous fatalities associated with exposure to DNP.
Recommend dosage of DNP Powders:
The recommend dosage is between 2-6mg/kg-bw per day for crystalline DNP and 4-10mg/kg-bw for powdered DNP.